High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays
نویسندگان
چکیده
Abstract Microneedle patches have received much interest in the last two decades as drug/vaccine delivery or fluid sampling systems for diagnostic and monitoring purposes. Microneedles are manufactured using a variety of additive subtractive micromanufacturing techniques. In decade, attention has been paid to manufacturing techniques both research industry, such 3D printing, fused deposition modeling, inkjet two-photon polymerization (2PP), with 2PP being most flexible method fabrication microneedle arrays. is one versatile precise processes, which enables arbitrary three-dimensional (3D) prototypes directly from computer-aided-design (CAD) models resolution down 100 nm. Due its unprecedented flexibility high spatial resolution, use this technology widespread bio-microdevices bio-nanodevices microneedles microfluidic devices. This pioneering transformative that facilitates complex miniaturized structures cannot be fabricated established multistep methods injection molding, photolithography, etching. Thus, microstructures designed according structural dynamics considerations rather than constraints imposed by machining etching processes. article presents fundamentals recent development array through unique manufacture microstructures, may overcome shortcomings conventional
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ژورنال
عنوان ژورنال: Microsystems & Nanoengineering
سال: 2021
ISSN: ['2055-7434', '2096-1030']
DOI: https://doi.org/10.1038/s41378-021-00298-3